![]() The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine's Advanced Computer Model. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 43. San Francisco is a three-point favorite in the latest 49ers vs. Kickoff from Lumen Field is set for 8:15 p.m. The Seahawks enter Thursday just behind the Commanders and Giants (both 7-5-1) for the last postseason spot. ![]() Meanwhile, Seattle (7-6) is in a dogfight for the third and final wild card spot in the NFC playoff picture. San Francisco (9-4) would clinch the NFC West title with a victory on TNF. In Week 2, the 49ers blew out the Seahawks, 27-7, behind a dominant defensive effort. ![]() The San Francisco 49ers can sweep the season series against the Seattle Seahawks for the first time since 2011 when the two NFC West rivals collide on Thursday Night Football game at Lumen Field. ![]()
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